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Page 1
Did you mean reca and prostatic neoplasms (3 results)?
RelB upregulates PD-L1 and exacerbates prostate cancer immune evasion.
Zhang Y, Zhu S, Du Y, Xu F, Sun W, Xu Z, Wang X, Qian P, Zhang Q, Feng J, Xu Y. Zhang Y, et al. J Exp Clin Cancer Res. 2022 Feb 17;41(1):66. doi: 10.1186/s13046-022-02243-2. J Exp Clin Cancer Res. 2022. PMID: 35177112 Free PMC article.
METHODS: Based on transcriptome results, RelB was manipulated in multiple human and murine PCa cell lines. Activated CD4(+) and CD8(+) T cells were cocultured with PCa cells with different levels of RelB to examine the effect of tumourous RelB on T cell immun …
METHODS: Based on transcriptome results, RelB was manipulated in multiple human and murine PCa cell lines. Activated CD4(+) and CD8(+ …
RelB promotes the migration and invasion of prostate cancer DU145 cells via exosomal ICAM1 in vitro.
Li W, Xu J, Cheng L, Zhao C, Zhang L, Shao Q, Guo F. Li W, et al. Cell Signal. 2022 Mar;91:110221. doi: 10.1016/j.cellsig.2021.110221. Epub 2021 Dec 18. Cell Signal. 2022. PMID: 34933092
RelB confers the aggressiveness to prostate cancer (PC) cells. Exosomes modulate the oncogenesis and progression of PC. ...Mechanistically, the expression of ICAM1, Integrin beta1, MMP9 and uPA were upregulated in RelB-knockdown cells upon hICAM1-exo treatment. Exos …
RelB confers the aggressiveness to prostate cancer (PC) cells. Exosomes modulate the oncogenesis and progression of PC. ...Mechanisti …
RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells.
Holley AK, Xu Y, St Clair DK, St Clair WH. Holley AK, et al. Ann N Y Acad Sci. 2010 Jul;1201:129-36. doi: 10.1111/j.1749-6632.2010.05613.x. Ann N Y Acad Sci. 2010. PMID: 20649549 Free PMC article. Review.
Blocking RelB activation suppresses MnSOD expression and sensitizes prostate cancer cells to radiation. These results suggest that RelB-mediated modulation of the antioxidant capacity of prostate cancer cells is an important mechanism of radiation resistance. ...
Blocking RelB activation suppresses MnSOD expression and sensitizes prostate cancer cells to radiation. These results suggest that …
The NF-kappaB subunit RelB regulates the migration and invasion abilities and the radio-sensitivity of prostate cancer cells.
Wang J, Yi S, Zhou J, Zhang Y, Guo F. Wang J, et al. Int J Oncol. 2016 Jul;49(1):381-92. doi: 10.3892/ijo.2016.3500. Epub 2016 Apr 25. Int J Oncol. 2016. PMID: 27121503
Here, we investigated systemically the functional roles of RelB in prostate cancer and examine its significance as a therapeutic target. ...Collectively, we provided evidence that RelB functioned as an oncogene in prostate cancer. Developing a RelB-targeted t …
Here, we investigated systemically the functional roles of RelB in prostate cancer and examine its significance as a therapeutic targ …
HZ08 suppresses RelB-activated MnSOD expression and enhances Radiosensitivity of prostate Cancer cells.
Zhang Y, Xu Z, Ding J, Tan C, Hu W, Li Y, Huang W, Xu Y. Zhang Y, et al. J Exp Clin Cancer Res. 2018 Jul 27;37(1):174. doi: 10.1186/s13046-018-0849-5. J Exp Clin Cancer Res. 2018. PMID: 30053873 Free PMC article.
The cellular levels of reactive oxygen species (ROS) and oxygen consumption rates (OCR) were measured using specific ROS detection probes and a Seahorse XF96 Analyzer, respectively. RelB binding to the NF-kappaB intronic enhancer region of the human SOD2 gene was determine …
The cellular levels of reactive oxygen species (ROS) and oxygen consumption rates (OCR) were measured using specific ROS detection probes an …
RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells.
Wei X, Xu Y, Xu FF, Chaiswing L, Schnell D, Noel T, Wang C, Chen J, St Clair DK, St Clair WH. Wei X, et al. Cancer Res. 2017 Mar 15;77(6):1345-1356. doi: 10.1158/0008-5472.CAN-16-0785. Epub 2017 Jan 20. Cancer Res. 2017. PMID: 28108513 Free PMC article.
Mechanistically, high reactive oxygen species concentrations suppress RelB in cancer cells. RelB suppression decreases expression of the sirtuin SIRT3 and the powerful antioxidant MnSOD, which in turn increases oxidative and metabolic stresses in prostate cancer cel …
Mechanistically, high reactive oxygen species concentrations suppress RelB in cancer cells. RelB suppression decreases express …
Endocrinotherapy resistance of prostate and breast cancer: Importance of the NF‑κB pathway (Review).
Wang X, Fang Y, Sun W, Xu Z, Zhang Y, Wei X, Ding X, Xu Y. Wang X, et al. Int J Oncol. 2020 May;56(5):1064-1074. doi: 10.3892/ijo.2020.4990. Epub 2020 Feb 19. Int J Oncol. 2020. PMID: 32319568 Review.
It was concluded that activation of the NF-kappaB pathway is an important common mechanism for metastasis and therapeutic resistance of the two types of cancer; in particular, the RelB-activated noncanonical NF-kappaB pathway appears to be able to lengthen and strengthen N …
It was concluded that activation of the NF-kappaB pathway is an important common mechanism for metastasis and therapeutic resistance of the …
The RelB-BLNK Axis Determines Cellular Response to a Novel Redox-Active Agent Betamethasone during Radiation Therapy in Prostate Cancer.
Chaiswing L, Xu F, Zhao Y, Thorson J, Wang C, He D, Lu J, Ellingson SR, Zhong W, Meyer K, Luo W, St Clair W, Clair DS. Chaiswing L, et al. Int J Mol Sci. 2022 Jun 8;23(12):6409. doi: 10.3390/ijms23126409. Int J Mol Sci. 2022. PMID: 35742868 Free PMC article.
Significantly, BET increases ROS levels and exerts different effects on RelB expression in normal cells and PCa cells. BET induces protein expression of RelB and RelB target genes, including the primary antioxidant enzyme, manganese superoxide dismutase (MnSO …
Significantly, BET increases ROS levels and exerts different effects on RelB expression in normal cells and PCa cells. BET induces pr …
RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells.
Josson S, Xu Y, Fang F, Dhar SK, St Clair DK, St Clair WH. Josson S, et al. Oncogene. 2006 Mar 9;25(10):1554-9. doi: 10.1038/sj.onc.1209186. Oncogene. 2006. PMID: 16261162 Free PMC article.
RelB is both constitutively present and is inducible by radiation in aggressive prostate cancer cells. ...Thus, inhibition of RelB could be a novel mechanism to radiosensitize prostate cancer....
RelB is both constitutively present and is inducible by radiation in aggressive prostate cancer cells. ...Thus, inhibition of RelB …
Molecular panorama of therapy resistance in prostate cancer: a pre-clinical and bioinformatics analysis for clinical translation.
Ashrafizadeh M, Zhang W, Tian Y, Sethi G, Zhang X, Qiu A. Ashrafizadeh M, et al. Cancer Metastasis Rev. 2024 Mar;43(1):229-260. doi: 10.1007/s10555-024-10168-9. Epub 2024 Feb 19. Cancer Metastasis Rev. 2024. PMID: 38374496 Review.
As a result of increase in DNA damage repair, PCa cells induce radioresistance and RelB overexpression prevents irradiation-mediated cell death. Similar to chemotherapy, nanomaterials are promising for promoting radiosensitivity through delivery of cargo, improving accumul …
As a result of increase in DNA damage repair, PCa cells induce radioresistance and RelB overexpression prevents irradiation-mediated …
30 results